ORCHARD PARK, N.Y. -- Once LeSean McCoy eluded two defenders and cut up the right sideline with nothing but the end zone in front of him, the Bills running back had time to glance up at the big screen and start celebrating.You can just hear the crowd yelling, McCoy said, recalling his 75-yard touchdown run on the first play from scrimmage in the second half. You feel the guy (behind you) and then you look on the screen and I know Ive got him beat.McCoys touchdown provided the Bills the spark they needed to persevere through a topsy-turvy second half and pull out a 28-21 win over the Jacksonville Jaguars on Sunday.It was McCoys second touchdown of the game, the longest of his career, and breathed life into a Tyrod Taylor-led offense that had managed just 63 yards of offense in the first half.Its huge. It gave the entire team life, guard Richie Incognito said.It provided a boost to Buffalos defense, too.Its like were back, said cornerback Nickell Robey-Coleman. Its like get back out there and do what we do. Fresh start.The Bills (6-5) won for the second straight week in which theyve trailed at the half to stay in the AFC playoff picture.And Taylor overcame a fourth-quarter deficit for just the second time in 25 games.Taylors 16-yard touchdown pass to Justin Hunter with 10:46 remaining put the Bills ahead for good, and he also scored on a 7-yard run.The game was decided with four minutes left, when the Jaguars were unable to convert a fourth-and-9 at the Buffalo 46. Blake Bortles hit Marquise Lee on a crossing pattern over the middle, but he was limited to a 4-yard gain.The Bills then took over and ran out the clock.The Jaguars (2-9) lost for the sixth straight game -- their longest skid since opening the 2014 season at 0-6. And they did so by blowing a fourth-quarter lead for the third time this season.We just cant get over the hill, said Jaguars defensive lineman Malik Jackson, who had two sacks.We have moral victories and thats good for us because were learning and were getting better, Jackson added. But when compared to the other 31 teams in the league, were not doing too good. And thats what we get graded on.Bortles went 13 of 26 for 126 yards and two touchdowns, and also had a career-best 81 yards rushing. The Jaguars, who entered the game with a league-high 22 giveaways, also didnt turn the ball over.Injuries, however, became an issue.Chris Ivory, who opened the scoring with a 2-yard run , was sidelined in the first half by a hamstring injury. And then Jacksonville lost receiver Allen Hurns, also with a hamstring injury while diving into the end zone on a 12-yard catch and run .The Bills overcame their growing list of injured players.McCoy, who also scored on a 2-point conversion, finished with 103 yards rushing and showed few signs of being bothered a week after having surgery for a dislocated left thumb.Receiver Sammy Watkins had three catches for 80 yards -- including a 62-yard reception -- playing his first game in nine weeks since aggravating an injury to his surgically repaired left foot.It just shows the resiliency of this bunch, Incognito said. It just keeps our dream alive.JAGS BIG OPENINGThe Jaguars snapped the NFLs longest active drought by scoring on their opening possession for the first time in 25 games. The streak began in Week 3 of the 2015 season, and featured the Jaguars combining for three field goals, punting 18 times and turning the ball over three times.Ivorys touchdown capped an 11-play, 75-yard drive spanning 6:45. The Jaguars converted three third-down chances, including their last one courtesy of a defensive holding penalty against Corey White on third-and-goal from the 3.SPECIAL TEAMSBills kicker Dan Carpenter missed his first point-after attempt wide left, his third this season. On the bright side for Buffalo, Brandon Tates 43-yard punt return late in the second quarter set up the Bills first score -- a five-play, 22-yard drive.INJURIESJaguars: Ivory (hamstring), WR Rashad Greene Sr. (Achilles) and FS Peyton Thompson (ankle) and Hurns (hamstring), who was hurt while diving into the end zone on his touchdown catch.Bills: CB Ronald Darby (concussion), WR Walter Powell (left ankle), DT Marcell Dareus (abdomen).NEXT UPJaguars: Host Denver on Dec. 4.Bills: At Oakland on Dec. 4.---For more NFL coverage:AP NFL website: www.pro32.ap.org and www.twitter.com/AP-NFLCheap Nashville Predators Jerseys . Newcastle dominated in the early stages but City weathered the storm and then raised its game in extra time. Negredo broke the deadlock from close range after a simple move in the 99th minute before Dzeko took the ball round goalkeeper Tim Krul to seal the victory in the 105th. 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MONROE, La. -- Caleb Evans threw for 279 yards and three touchdowns, including a 7-yard touchdown pass to Marcus Green in overtime to lift Louisiana-Monroe to a 42-35 victory over South Alabama on Saturday night.Louisiana-Monroe (3-6, 2/3 Sun Belt Conference) had the first possession of overtime. The Warhawks Cortez Sisco Jr. sacked Dallas Davis on a fourth-and-12 to end the game.Evans was 26-of-38 passing and connected with Rj Turner and Xavier Brown for scores. Thomas Koufie ran for two touchdowns in the fourth quarter to give LLouisiana-Monroe a 35-28 lead with about four minutes left.ddddddddddddDami Ayoola scored on a 14-yard touchdown run for the Jaguars to tie it at 35-35. The Warhawks then drove to the South Alabama 39 when Chris Henderson intercepted Evans and ran to the Louisiana-Monroe 33-yard line with five seconds left. But Sisco blocked Gavin Pattersons 50-yard field goal attempt as time expired to force overtime. 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